Preprint has been published in a journal as an article
Preprint / Version 1

Correlation between Urine Albumin Creatinin Ratio (UACR) Value to Urine Osmolality Value and Estimate Glomerular Filtration Rate (EGFR) Value on Patient with Kidney Failure


Korelasi antara Nilai Urine Albumin Creatinin Ratio (UACR) terhadap Nilai Osmolalitas Urin dan Nilai Estimate Glomerular Filtration Rate (EGFR) pada Pasien Gagal Ginjal

##article.authors##

DOI:

https://doi.org/10.21070/ups.5585

Keywords:

UACR, Urine Osmolality, EGFR, Kidney Failure

Abstract

Urine Albumin Creatinin Ratio (UACR), urine osmolality and Estimate Glomerular Filtration Rate (EGFR) are laboratory examination parameters used to evaluate kidney function. The purpose of this study was to determine the correlation between UACR values to urine osmolality values and EGFR values in patients with kidney failure. This study is an analytic observational quantitative study through a cross sectional design using 30 samples conducted from May to June 2024 at the Central Laboratory Installation of Dr. Saiful Anwar Hospital, East Java Province. UACR and EGFR examinations use the principle of photometric tests while urine osmolality examinations use the principle of electrical conductivity. The data were analyzed using the Shapiro-Wilk normality test and the Spearman correlation test through SPSS 27. The results of this study showed no correlation between UACR values to urine osmolality values (p = 0,342) or EGFR values (p = 0,481) in patients with kidney failure.

Downloads

Download data is not yet available.

References

E. Syahputra, E. K. Laoli, J. Alyah, E. Y. Bahagia HBS, E. Y. E. br. Tumorang, and T. Nababan, “Dukungan Keluarga Berhubungan Dengan Kualitas Hidup Pasien Gagal Ginjal Kronik Yang Menjalani Terapi Hemodialisa,” J. Penelit. Perawat Prof., vol. 4, pp. 793–800, 2022, [Online]. Available: https://jurnal.globalhealthsciencegroup.com/index.php/JPPP/article/view/977

Riskesdas Kementrian Kesehatan RI, “Laporan Riskesdas 2018 Nasional.pdf,” Lembaga Penerbit Balitbangkes. 2019. [Online]. Available: https://repository.badankebijakan.kemkes.go.id/id/eprint/3514/1/Laporan Riskesdas 2018 Nasional.pdf

V. Gounden, H. Bhatt, and I. Jialal, Renal Function Tests. StatPearls Publishing, 2023. [Online]. Available: https://www.ncbi.nlm.nih.gov/books/NBK507821/

H. Susianti, Memahami Interpretasi Pemeriksaan Laboratorium Penyakit Ginjal Kronis. Malang: UB Press, 2019.

N. G. Larkins et al., “Albuminuria: Population epidemiology and concordance in Australian children aged 11-12 years and their parents,” BMJ Open, vol. 9, pp. 75–84, 2019, doi: 10.1136/bmjopen-2017-020262.

S. L. Afera, S. D. Santoso, and R. I. Santosa, “Rasio Albumin Kreatinin Urin Sebagai Deteksi Dini Gangguan Fungsi Ginjal Pada Diabetes Melitus,” J. SainHealth, vol. 5, no. 2, pp. 1–5, 2021, [Online]. Available: https://e-journal.umaha.ac.id/index.php/sainhealth/article/view/1516

M. Oshima et al., “Combined changes in albuminuria and kidney function and subsequent risk for kidney failure in type 2 diabetes,” BMJ Open Diabetes Res. Care, vol. 9, no. 1, 2021, doi: 10.1136/bmjdrc-2021-002311.

A. S. Levey et al., “Change in Albuminuria and GFR as End Points for Clinical Trials in Early Stages of CKD: A Scientific Workshop Sponsored by the National Kidney Foundation in Collaboration With the US Food and Drug Administration and European Medicines Agency,” Am. J. Kidney Dis., vol. 75, no. 1, pp. 84–104, 2020, doi: 10.1053/j.ajkd.2019.06.009.

D. A. Q. Milani and I. Jialal, Urinalysis. StatPearls Publishing, 2023. [Online]. Available: https://www.ncbi.nlm.nih.gov/books/NBK557685/

D. W. Yoo, S. M. Lee, S. Y. Moon, I. S. Kim, and C. L. Chang, “Evaluation of conductivity-based osmolality measurement in urine using the Sysmex UF5000,” J. Clin. Lab. Anal., vol. 35, no. 1, pp. 1–7, 2021, doi: 10.1002/jcla.23586.

M. J. Lee et al., “Urine Osmolality and Renal Outcome in Patients with Chronic Kidney Disease: Results from the KNOW-CKD,” Kidney Blood Press. Res., vol. 44, no. 5, pp. 1089–1100, 2019, doi: 10.1159/000502291.

B. K. Kitiwan, S. M. Vasunilashorn, H. J. Baer, K. Mukamal, and S. P. Juraschek, “The association of urine osmolality with decreased kidney function and/or albuminuria in the United States,” BMC Nephrol., vol. 22, no. 1, pp. 1–11, 2021, doi: 10.1186/s12882-021-02478-9.

W. G. Miller et al., “National Kidney Foundation Laboratory Engagement Working Group Recommendations for Implementing the CKD-EPI 2021 Race-Free Equations for Estimated Glomerular Filtration Rate: Practical Guidance for Clinical Laboratories,” Clin. Chem., vol. 68, no. 4, pp. 511–520, 2022, doi: 10.1093/clinchem/hvab278.

S. Yaqub, S. Hashmi, M. K. Kazmi, A. A. Ali, T. Dawood, and H. Sharif, “A Comparison of AKIN, KDIGO, and RIFLE Definitions to Diagnose Acute Kidney Injury and Predict the Outcomes after Cardiac Surgery in a South Asian Cohort,” Cardio Renal Med., vol. 12, no. 1, pp. 29–38, 2022, doi: 10.1159/000523828.

KDIGO, “Clinical practice guideline for evaluation and manegement of chronic disease,” Kidney Int. Suppl., no. July, 2023.

M. C. . Larkins, M. Zubair, and A. Thombare, Osmometer. StatPearls Publishing, 2024. [Online]. Available: https://www.ncbi.nlm.nih.gov/books/NBK589659/

M. Oyaert, M. M. Speeckaert, and J. R. Delanghe, “Estimated urinary osmolality based on combined urinalysis parameters: a critical evaluation,” Clin. Chem. Lab. Med., vol. 57, no. 8, pp. 1169–1176, 2019, doi: 10.1515/cclm-2018-1307.

Posted

2024-08-05