Correlation Procalcitonin, Neutrofil to Lymphocyte Ratio (NLR) and C-Reactive Protein (CRP) in Patients Sepsis with Acute Kidney Failure
Korelasi Prokalsitonin terhadap Neutrofil to Lymphocyte Ratio (NLR) dan C-Reactive Protein (CRP) pada Pasien Sepsis dengan Gagal Ginjal Akut
DOI:
https://doi.org/10.21070/ups.5556Keywords:
Sepsis, Acut Kidney Failure, Procalcitonin, Neutrofil Lymphosit Ratio (NLR), C-reactive protein (CRP)Abstract
Sepsis can be defined as organ dysfunction caused by a dysregulated host response to infection. Early identification in the diagnosis of sepsis is crucial for appropriate management. Delays in the diagnosis and treatment of severe sepsis, septic shock, multiple organ dysfunction, or even death can occur. Acute kidney injury (AKI) is the most severe and common comorbidity in sepsis. Procalcitonin (PCT), Neutrophil-Lymphocyte Ratio (NLR), and C-reactive protein (CRP) are important markers of sepsis. This study aims to determine the relationship between PCT, NLR, and CRP in sepsis patients with acute kidney injury. The study was conducted at the Central Laboratory Installation of Dr. Saiful Anwar Hospital Malang from January to May 2024. This observational analytic study used 30 samples. The data were tested using Pearson correlation and it was found that there is a correlation between procalcitonin and NLR (p=0.017; r=0.434), a correlation between procalcitonin and CRP (p=0.027; r=0.403)
Downloads
References
KDIGO, “Scope of Work KDIGO Clinical Practice Guideline for Acute Kidney Injury (AKI) and Acute Kidney Disease (AKD) Update 2023,” 2023.
F. D. Omar et al., “Clinical Characteristics of Acute Kidney Injury Associated with Tropical Acute Febrile Illness,” Trop Med Infect Dis, vol. 8, no. 3, 2023, doi: 10.3390/tropicalmed8030147.
J. Jonny et al., “Incidence of acute kidney injury and use of renal replacement therapy in intensive care unit patients in Indonesia,” BMC Nephrol, vol. 21, no. 1, pp. 1–8, 2020, doi: 10.1186/s12882-020-01849-y.
F. F. He, Y. M. Wang, Y. Y. Chen, W. Huang, Z. Q. Li, and C. Zhang, “Sepsis-induced AKI: From pathogenesis to therapeutic approaches,” Front Pharmacol, vol. 13, no. September, pp. 1–15, 2022, doi: 10.3389/fphar.2022.981578.
J. Hassan et al., “Role of Procalcitonin and C-reactive Protein as Predictors of Sepsis and in Managing Sepsis in Postoperative Patients: A Systematic Review,” Cureus, vol. 14, no. 11, pp. 1–13, 2022, doi: 10.7759/cureus.31067.
S. Dugar, C. Choudhary, and A. Duggal, “Sepsis and septic shock: Guideline-based management,” Cleve Clin J Med, vol. 87, no. 1, pp. 53–64, 2020, doi: 10.3949/ccjm.87a.18143.
L. Y. Id, M. Feng, Q. Lin, F. Li, and J. L. Id, “Analysis of pathogenic factors on the death rate of sepsis patients,” pp. 1–14, 2023, doi: 10.1371/journal.pone.0287254.
I. A. Dafitri, O. Khairsyaf, I. Medison, and Y. S. Sabri, “Korelasi qSOFA dan NLR Terhadap Kadar Prokalsitonin Untuk Memprediksi Luaran Pasien Sepsis Pneumonia di RSUP dr. M. DJAMIL Padang,” J Respir Indo, vol. 40, no. 3, pp. 173–6, 2020, [Online]. Available: http://www.jurnalrespirologi.org
Y. Sui, W. Xin, and L. Feng, “Comparison of the clinical application values of PCT, hs-CRP and SAA detection in the early diagnosis of sepsis,” Pak J Med Sci, vol. 36, no. 7, pp. 1683–1687, Oct. 2020, doi: 10.12669/pjms.36.7.2544.
G. Cioni, J. Canini, and F. Pieralli, “Procalcitonin in clinical practice: from diagnosis of sepsis to antibiotic therapy,” Italian Journal of Medicine, vol. 15, no. 1, pp. 7–16, Mar. 2021, doi: 10.4081/itjm.2021.1438.
A. Megawati and A. Aliviameita, “Hubungan Jumlah Leukosit dan Kadar CRP (C-Reactive Protein) Pada Pasien Demam Tifoid,” Academia Open, vol. 4, pp. 1–10, 2021.
I. Kurniati, F. S. Arisqan, and U. G. Mutiara, “Differences in Neutrophil Lymphocyte Ratio (NLR) between Sepsis and Septic Shock Patients in a Tertiary Hospital in Indonesia,” Majalah Kedokteran Bandung, vol. 55, no. 3, pp. 149–153, 2023, doi: 10.15395/mkb.v55n3.3149.
A. Q. Jaelani, S. K. Arif, F. Muchtar, H. Nurdin, S. H. Salam, and A. H. Tanra, “Hubungan Neutrophil-Lymphocyte Ratio dengan Kejadian Acute Kidney Injury Pada Pasien Sepsis yang Dirawat di Intensive Care Unit (ICU),” Majalah Anestesia & Critical Care, vol. 41, no. 3, pp. 143–154, 2023, doi: 10.55497/majanestcricar.v41i3.304.
T. Schupp et al., “C-reactive protein and procalcitonin during course of sepsis and septic shock,” Ir J Med Sci, vol. 193, no. 1, pp. 457–468, 2024, doi: 10.1007/s11845-023-03385-8.
N. S. WINARNO, N. ARKHAESI, MULYONO, G. HARDANINGSI, and E. K. S. LIMIJADI, “Relationship Between CRP, Procalcitonin, I/T Ratio and The Incidence of Sepsis in Children,” Medicina Moderna - Modern Medicine, vol. 30, no. 3, pp. 227–233, Sep. 2023, doi: 10.31689/rmm.2023.30.3.227.
P. Liang and F. Yu, “Value of CRP, PCT, and NLR in Prediction of Severity and Prognosis of Patients With Bloodstream Infections and Sepsis,” Front Surg, vol. 9, no. March, pp. 1–7, Mar. 2022, doi: 10.3389/fsurg.2022.857218.
M. D. Mweene, G. A. Richards, G. Paget, J. Banda, and C. Dickens, “Risk factors and outcomes of sepsis-associated acute kidney injury in intensive care units in Johannesburg, South Africa,” South African Medical Journal, vol. 112, no. 12, pp. 919–923, 2022, doi: 10.7196/SAMJ.2022.v112i12.16410.
L. Lin et al., “Construction and validation of a risk prediction model for acute kidney injury in patients after cardiac arrest,” Ren Fail, vol. 45, no. 2, 2023, doi: 10.1080/0886022X.2023.2285865.
N. Z. Elhapidi, P. A. Kalew, E. G. Darmadji, I. A. R. Pake, and S. Regina, “Risk Prediction Acute Kidney Injury Pada Pasien Sepsis,” Suplemen HIJP: Health Information Jurnal Penelitian, vol. 15, pp. 1–16, 2023, [Online]. Available: https://myjurnal.poltekkes-kdi.ac.id/index.php/hijp
S. Y. Min, H. J. Yong, and D. Kim, “Sex or gender differences in treatment outcomes of sepsis and septic shock,” Acute and Critical Care, vol. 39, no. 2, pp. 207–213, 2024, doi: 10.4266/acc.2024.00591.
I. Lakbar, S. Einav, N. Lalevée, I. Martin-Loeches, B. Pastene, and M. Leone, “Interactions between Gender and Sepsis—Implications for the Future,” Microorganisms, vol. 11, no. 3, pp. 1–16, 2023, doi: 10.3390/microorganisms11030746.
B. Gyawali, K. Ramakrishna, and A. S. Dhamoon, “Sepsis: The evolution in definition, pathophysiology, and management,” SAGE Open Med, vol. 7, 2019, doi: 10.1177/2050312119835043.
T. Tian, B. Wei, and J. Wang, “Study of C-reactive protein, procalcitonin, and immunocyte ratios in 194 patients with sepsis,” BMC Emerg Med, vol. 21, no. 1, pp. 1–8, 2021, doi: 10.1186/s12873-021-00477-5.
N. Cui, H. Zhang, Z. Chen, and Z. Yu, “Prognostic significance of PCT and CRP evaluation for adult ICU patients with sepsis and septic shock: retrospective analysis of 59 cases,” Journal of International Medical Research, vol. 47, no. 4, pp. 1573–1579, 2019, doi: 10.1177/0300060518822404.
S. Ding et al., “Diagnostic Accuracy of Procalcitonin, Neutrophil-to-Lymphocyte Ratio, and C-Reactive Protein in Detection of Bacterial Infections and Prediction of Outcome in Nonneutropenic Febrile Patients with Lung Malignancy,” J Oncol, vol. 2020, 2020, doi: 10.1155/2020/2192378.
Downloads
Additional Files
Posted
License
Copyright (c) 2024 UMSIDA Preprints Server
This work is licensed under a Creative Commons Attribution 4.0 International License.
