Analysis of the 6174delT Mutation in the BRCA2 Gene in Families at Risk for Breast Cancer
Analisis Mutasi 6174delT Pada Gen BRCA2 dalam Keluarga yang Berisiko Kanker Payudara
DOI:
https://doi.org/10.21070/ups.8455Keywords:
Breast cancer, BRCA2 gene, Mutation 6174delT, MS-PCRAbstract
Cancer is the second most common cause of death. One of the most common and dangerous types of cancer in women is Breast Cancer (Ca Mamae). The most significant risk factor for breast cancer is family history. This study aims to analyze the 6174delT mutation of the BRCA2 gene in families at risk of breast cancer and have a history of cancer. This study uses a Descriptive Correlative research design. Sampling was carried out by Purposive Sampling. This study uses a descriptive method to test the relationship between age category variables and clinical diagnosis with the occurrence of 6174delT mutation using the Fisher Exact Test via SPSS version 23. The results of the 6174delT mutation analysis study on the BRCA2 gene showes that 3 samples had a Heterozygous genotype meaning carries of the 6174delT mutation, while 7 samples showed a Homozygous Wildtype genotype meaning there was no 6174delT mutation.
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