Mutation Analysis Of Rs7903146 Transcription Factor 7 Like 2 (TCF7L2) Gene In Type Ii Diabetes Mellitus Sufferers Using The PCR-RFLP Method
Analisis Mutasi rs 7903146 gen TCF7L2 Pada Penderita Diabetes Mellitus Tipe 2 di Sidoarjo Menggunakan Metode Pcr-rflp
DOI:
https://doi.org/10.21070/ups.7314Keywords:
Diabetes Mellitus Type 2, PCR Rflp Tcf7l2, SNP rs7903146, SidoarjoAbstract
Diabetes mellitus (DM) is a series of metabolic abnormalities characterized by increased blood glucose levels (hyperglycemia), which is caused by impaired insulin release, insulin function. The TCF7L2 gene is a gene associated with susceptibility to type 2 diabetes mellitus (T2). Research by Beloso found mutations in the TCF7L2 gene with variations in the SNP rs7903146, which showed a significant correlation with type 2 diabetes. The purpose of this study was to analyze the rs7903146 mutation of the TCF7L2 gene in T2 patients in the Sidoarjo area using the PCR RFLP method. This study uses a descriptive research type with a qualitative approach. This research was conducted at the Molecular Biology Laboratory, Faculty of Health Sciences, Muhammadiyah University of Sidoarjo, in July-August 2024.
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