Differences in ALP and Gamma GT levels of Hepar Male White Rats (Rattus norvegicus) Induced by Toxic Doses of Paracetamol by Administration of Turi Leaf Extract (Sesbania grandiflora (L.) Pers.)
Perbedaan kadar ALP dan Gamma GT Hepar Tikus Putih Jantan (Rattus norvegicus) yang di Induksi Parasetamol Dosis Toksik dengan Pemberian Ekstrak Daun Turi (Sesbania grandiflora (L.) Pers.)
DOI:
https://doi.org/10.21070/ups.9300Keywords:
ALP, Antioxidant, Turi leaf, Gamma GT, Paracetamol, MDA, Liver of Rattus norvegicusAbstract
(Sesbania grandiflora (L.) Pers.) contains bioactive compounds such as alkaloids, flavonoids, and tannins, which exhibit natural antioxidant activity. This study involved 28 rats divided into 7 groups, including a negative control and treatment groups receiving turi leaf extract at doses of 500, 750, and 1000 mg/kgBW. Malondialdehyde (MDA) levels were measured as indicators of oxidative stress, while Alkaline Phosphatase (ALP) and Gamma Glutamyl Transferase (GGT) were assessed to evaluate liver damage. One Way ANOVA showed significant differences in MDA and ALP levels (p<0.05), whereas the Kruskal-Wallis test revealed significant differences in ALP extract and GGT levels (p<0.05). Administration of the 1000 mg/kgBW dose was most effective in reducing MDA, ALP, and GGT levels close to normal values, indicating the hepatoprotective potential of turi leaf extract against paracetamol-induced liver injury.
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