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Effectiveness of Bay Leaf Extract (Syzygium polyanthum (Wight) Walp.) on Reducing Lead (Pb) Levels in Vivo in Wistar Rats (Rattus norvegicus)

Efektivitas Ekstrak Daun Salam (Syzygium polyanthum (Wight) Walp.) terhadap Penurunan Kadar Logam Berat Timbal (Pb) pada Tikus Wistar  (Rattus norvegicus) secara In Vivo

Authors

DOI:

https://doi.org/10.21070/aw58tk52

Keywords:

Bay leaf (Syzygium polyanthum (Wight) Walp.), Lead (Pb); Rattus norvegicus, Atomic Absorption Spectrophotometer (AAS)

Abstract

Lead (Pb) is a toxic heavy metal that can accumulate in the body and cause various health problems. Bay leaves (Syzygium polyanthum (Wight) Walp.) contain flavonoids, tannins, alkaloids, saponins, and phenolic compounds that may act as antioxidants and bind heavy metals. This study aimed to determine the effectiveness and optimal dose of bay leaf extract in reducing blood Pb levels in Wistar rats (Rattus norvegicus) induced with lead acetate (700 mg/kgBW). An in vivo laboratory experiment using a pre-test post-test control group design was conducted on 24 male rats divided into six groups. Blood Pb levels were measured using Atomic Absorption Spectrophotometry (AAS) and analyzed using the Wilcoxon test in SPSS version 25. The results showed a p-value of 0.068 (p>0.05), indicating no statistically significant difference before and after treatment. Bay leaf extract descriptively reduced blood Pb levels, but increasing the dose did not produce a statistically significant effect.

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Posted

2026-11-04