The Relationship Between Acute Inflammatory Biomarkers (LED and CRP) and Blood Sugar Levels With GeneXpert MTB/RIF Test Results in Suspected Pulmonary TB Cases
Hubungan Biomarker Inflamasi Akut (LED dan CRP) dengan Kadar Gula Darah Terhadap Hasil Pemeriksaan GeneXpert MTB/RIF pada Terduga TB Paru
DOI:
https://doi.org/10.21070/ups.11407Keywords:
- Tuberculosis (TB), Erythrocyte Sedimentation Rate (ESR), C-reactive protein (CRP), Random Blood Glucose (RBG)Abstract
Tuberculosis (TB) diagnosis using the GeneXpert MTB/RIF is limited by accessibility and turnaround time at primary healthcare facilities. This study aims to analyze the relationship between Erythrocyte Sedimentation Rate (ESR), C- Reactive Protein (CRP), and random blood glucose (RBG) with GeneXpert results. An analytical observational design with a restrospective cross-sectional approach was conducted on 58 suspected TB patients at Poncokusumo Public Health from January to April 2026. Statistical analysis revealed a strong and highly significant correlation between CRP and GeneXpert results (r = 0.721), between CRP and ESR (r = 0.701) as well as between ESR and GeneXpert (r = 0.636). Conversely, RBG and GeneXpert showed a weak, non significant correlation (r = 0.200). In conclusion, inflammatory biomarkers (ESR and CRP) strongly reflect bacterial load in TB infection. Therefore RBG levels cannot yet be used as a meaningful indicator reflecting the degree of inflammation or GeneXpert outcomes in this study.
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References
World Health Organization, Global Tuberculosis Report 2024. Geneva, Switzerland: WHO, 2024.
World Health Organization, Global Tuberculosis Report 2025. Geneva, Switzerland: WHO, 2025.
Tim Kerja Tuberkulosis P2P Kemenkes RI, Revisi Strategi Nasional Penanggulangan Tuberkulosis di Indonesia 2020-2024 dan Rencana Interim 2025-2026. Jakarta, Indonesia: Kemenkes RI, 2023.
O. S. Simarmata and D. B. Lolong, “Evaluasi Keunggulan Tes Cepat Molekuler dengan Xpert MTB/ RIF Dibanding dengan Uji Mikroskopis dalam Mendiagnosis Tuberkulosis di Indonesia Tahun 2018,” Buletin Penelitian Kesehatan, vol. 48, no. 2, pp. 109–116, Sep. 2020, https://doi.org/10.22435/bpk.v48i2.2875.
N. N. Mahartini, J. Nugraha, and S. Ma’at, “Correlation between serum IL-17 levels with Erythrocyte Sedimentation Rate (ESR) and C-Reactive Protein (CRP) levels of new cases of pulmonary tuberculosis at Sanglah Central General Hospital, Bali, Indonesia,” Indonesia Journal of Biomedical Science, vol. 16, no. 1, pp. 70–73, Jun. 2022, https://doi.org/10.15562/ijbs.v16i1.391.
A. Tahumuri, M. C. P. Wongkar, and L. A. Rotty, “Gambaran Laju Endap darah dan C-Reactive Protein Pada Pasien Tuberkulosis Paru Di Manado 2016,” Jurnal Kedokteran Klinik, vol. 1, no. 3, pp. 36–42, Mei 2017.
T. Listiyowati, D. Pratiwi, K. Wardani, T. A. Sudarsono, and L. Wijayanti, “Relationship Between Results of Genexpert RT-PCR and Erythrocyte Sedimentation Rate in Suspected Tuberculosis Patients,” Jurnal Ilmiah Teknologi Kesehatan, vol. 10, no. 2, pp. 58–63, Nov. 2023, https://doi.org/10.32668/jitek.v10ii.1078.
I. B. Aditya Nugraha, W. Gotera, and W. E. F. Yustin, “Diabetes Melitus Sebagai Faktor Risiko Tuberkulosis,” Jurnal Kedokteran Meditek, vol. 27, no. 3, pp. 273–281, Sep. 2021, https://doi.org/10.36452/jkdoktmeditek.v27i3.2126.
Badan Kebijakan Pembangunan Kesehatan, Survei Kesehatan Indonesia (SKI) 2023 Dalam Angka. Jakarta, Indonesia: Kementerian Kesehatan Republik Indonesia, 2023.
D. B. Sacks et al., “Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus,” Diabetes Care, vol. 46, no. 10, pp. e151–e199, Oct. 2023, https://doi.org/10.2337/dci23-0036.
H. Gunasekaran, U. D. Ranganathan, and R. Bethunaickan, “The importance of inflammatory biomarkers in detecting and managing latent tuberculosis infection,” Frontiers in Immunology, vol. 16, Feb. 2025, Art. no. 1538127, https://doi.org/10.3389/fimmu.2025.1538127.
M. Khalil, H. A. A. Halim, and M. Abdelazeem, “C-reactive protein versus erythrocyte sedimentation rate in monitoring multidrug-resistant tuberculosis,” Egyptian Journal of Chest Diseases and Tuberculosis, vol. 69, no. 3, p. 458, Jul.–Sep. 2020, https://doi.org/10.4103/ejcdt.ejcdt_113_19.
N. P. Kumar et al., “Acute Phase Proteins Are Baseline Predictors of Tuberculosis Treatment Failure,” Frontiers in Immunology, vol. 12, Nov. 2021, Art. no. 731878, https://doi.org/10.3389/fimmu.2021.731878.
World Health Organization, WHO Consolidated guidelines on TB Module 2: Screening. Geneva, Switzerland: WHO, 2021.
S. B. Nyamagoud, P. D. Dsouza, S. P. P. Chitralu, K. Solankure, and A. H. V. Swamy, “Evaluating hematological and inflammatory biomarkers in tuberculosis management,” Monaldi Archives for Chest Disease, Jul. 2025, https://doi.org/10.4081/monaldi.2025.3433.
B. A. Al-Ofairi, M. A. Al-Jahrani, A. Esmail, A. M. Abdulkareem, and M. K. Saeed, “Assessment of some hematological and inflammatory parameters among patients with active pulmonary tuberculosis in Ibb governorate, Yemen,” BMC Infectious Diseases, vol. 25, Dec. 2025, Art. no. 12261, https://doi.org/10.1186/s12879-025-12261-y.
M. Byers and E. Guy, “The Complex Relationship Between Tuberculosis and Hyperglycemia,” Diagnostics, vol. 14, no. 22, Nov. 2024, Art. no. 2539, https://doi.org/10.3390/diagnostics14222539.
U. Abbas et al., “Tuberculosis and diabetes mellitus: Relating immune impact of co-morbidity with challenges in disease management in high burden countries,” Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, vol. 29, Dec. 2022, Art. no. 100343, https://doi.org/10.1016/j.jctube.2022.100343.
Z. Chen et al., “The association of glycemic level and prevalence of tuberculosis: a meta-analysis,” BMC Endocrine Disorders, vol. 21, no. 1, Dec. 2021, Art. no. 77, https://doi.org/10.1186/s12902-021-00779-6.
M. D. Ngo, S. Bartlett, and K. Ronacher, “Diabetes‐associated susceptibility to tuberculosis: Contribution of hyperglycemia vs. dyslipidemia,” Microorganisms, vol. 9, no. 11, Nov. 2021, Art. no. 2282, https://doi.org/10.3390/microorganisms9112282.
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