The Effectiveness of Gracilaria verrucosa Seaweed Extract on Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), and Mean Corpuscular Hemoglobin Concentration (MCHC) Levels in White Rats (Rattus norvegicus) with Hyperlipidemia
Efektifitas Ekstrak Rumput Laut Gracilaria verrucosa Terhadap Kadar Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), dan Mean Corpuscular Hemoglobin Concentration (MCHC) Pada Tikus Putih (Rattus norvegicus) Dengan Kondisi Hiperlipidemia
DOI:
https://doi.org/10.21070/ups.11331Keywords:
Hyperlipidemia, Gracilaria verrucosa, MCV, MCH, MCHCAbstract
Hyperlipidemia is a metabolic disorder characterized by increased total cholesterol that can trigger oxidative stress and lipid peroxidation in erythrocyte membranes, potentially causing hemolysis and decreased hematological parameters. Gracilaria verrucosa contains bioactive compounds such as flavonoids, phenols, tannins, alkaloids, steroids, and saponins that act as antioxidants in suppressing oxidative stress caused by hyperlipidemia. The study used a pretest-posttest control group design conducted during April–May 2026 using 25 male Wistar rats (Rattus norvegicus) with hyperlipidemia groups: negative control, positive control (simvastatin 0.18 mg/200 gBW), and extract treatment doses of 25 mg/200 gBW, 35 mg/200 gBW, and 45 mg/200 gBW. Gracilaria verrucosa extract had a significant effect on MCV (p=0.000) and MCH (p=0.000) values, whereas it did not show a significant effect on MCHC values (p=0.178). The results indicate that Gracilaria verrucosa extract effectively increased MCV and MCH values, with the most effective dose being 25 mg/200 gBW.
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